7OH, short for7-hydroxymitragynine, is one of the most powerful alkaloids found in the kratom plant (Mitragyna speciosa). While it exists naturally only in trace amounts, some manufacturers are now isolating, concentrating, or even synthesizing it—and selling it invape form.

That convenience and potency make 7OH vapes attractive, but also extremely risky. Here’s everything you need to know about what 7OH is, how it works, and why health officials are sounding the alarm.

Quick Facts About 7OH Vapes

• Source: Derived from kratom or synthesized in labs
  

• Potency:Up to13x stronger than morphine at the μ-opioid receptor
  

• Onset:Seconds when vaped (vs. 30–45 minutes in raw kratom)
  

• Effects: Pain relief, euphoria, sedation, appetite changes
  

• Risks: Dependence, withdrawal, respiratory depression, legal issues
  

How 7OH Works

In traditional kratom use, your body naturally metabolizesmitragynine into 7OH. This slow conversion explains why kratom tea or capsules take time to kick in.

But when you inhale7OH directly through a vape, you’re bypassing your body’s natural filters. The compound is absorbed almost instantly into the bloodstream, triggering powerful opioid-like effects far stronger than standard kratom.

Effects of 7OH Vapes

Reported positive effects:

• Intense pain relief
  

• Euphoria and mood enhancement
  

• Relaxation and calm
  

• Sleepiness (at higher doses)
  

Reported negative effects:

• Drowsiness, dizziness, confusion
  

• Nausea or vomiting
  

• Impaired coordination
  

• Respiratory depression (slowed or stopped breathing at high doses)
  

• Severe tolerance and dependence
  
  

How 7OH Vapes Compare to Other Forms

Is 7OH Safe?

Simply put:No.

7OH is far more potent than morphine, yet it’s being sold in flavored vape pens that look like nicotine devices. That mix ofhigh potency, unregulated production, and attractive packaging makes it a major public health concern.

TheFDA and state governments (like Florida) are already moving to restrict or ban it. In July 2025, the FDA recommended scheduling 7OH under theControlled Substances Act, likely placing it in the same category as opioids.

Frequently Asked Questions

Does 7OH get you high?

Yes. Users report euphoria, sedation, and pain relief, but also confusion and grogginess.

 Is 7OH the same as kratom?

Not exactly. Kratom contains many alkaloids, with mitragynine being the most common. 7OH is a potent byproduct—and in vape form, it’s unnaturally concentrated.

Is 7OH legal?

It depends. The FDA has urged federal scheduling, and states like Florida have already banned it. Laws vary, but the trend is toward restriction.

Can you overdose on 7OH vapes?

Yes. Because it acts like a strong opioid, high doses can slow or stop breathing. The risk is significantly higher with vaping due to rapid absorption.

Is 7OH addictive?

Yes. Like opioids, repeated use can quickly lead to tolerance, dependence, and withdrawal symptoms if you stop.

The Bottom Line

7OH in vapes is7-hydroxymitragynine—a kratom alkaloid that’s many times stronger than morphine. In vape form, it deliversinstant and powerful opioid-like effects, but at the cost of safety, legality, and long-term health.

While marketed as a trendy alternative,7OH vapes are high-risk and increasingly targeted by regulators. If you’re considering them, be aware: the dangers far outweigh the hype.