Etomidate is a potent anesthetic typically used in medical settings for rapid sedation and anesthesia—so when it shows up in a vape, the implications are alarmingly serious. Here's what to know aboutetomidate in vapes, why it’s being referred to as "K-pods" or "space oil," and why regulators are sounding the alarm.

What Is Etomidate?

• Medical origins: Etomidate is a short-acting, non-barbiturate sedative-hypnotic used intravenously to induce anesthesia—commonly during emergency procedures like intubation and electroconvulsive therapy.
  

• How it works: It enhances inhibitory signals in the brain by modulating GABAA_AA receptors, producing rapid sedation with minimal cardiovascular impact.
  

• Onset and duration:Effects begin within seconds (typically 30–60 seconds) and last just a few minutes.
  

How Etomidate Is Appearing in Vapes

• In recent years, illicit vape products—often dubbed“K-pods” or“space oil”—have been found containing etomidate and its analogs (like metomidate and isopropoxate) in e-liquids.
  

• These substances are not intended for inhalation but are being added to vaping fluids for their sedative effects—even though they are illicit and extremely dangerous in that form.
  

The Dangers of Vaping Etomidate

1. Severe sedation and loss of control:Etomidate acts rapidly once inhaled—far faster than traditional ingestion routes—and can cause intense sedation that leads to confusion, falls, or “zombie-like behavior.” 
   

2. Adrenal insufficiency:Etomidate can suppress cortisol production in the adrenal glands. In Hong Kong, several cases ofadrenal insufficiency were reported in adolescents after vaping “space oil,” leading to long-lasting endocrine issues.
   

3. Neurological and psychiatric effects:Users may experience tremors, muscle spasms, psychosis, mood swings, or suicidal thoughts. Long-term use may also elevate the risk for severe mental health issues.
   

Growing Regulatory Response

• Singapore has ramped up enforcement.Starting September 2025, etomidate was reclassified as adrug, escalating penalties for vape users and distributors. Users face fines and rehabilitation; sellers face up to 20 years in prison.
  

• Hong Kong designated etomidate as a controlled drug under its Dangerous Drugs Ordinance. Illicit vaping products containing it may lead to life imprisonment and massive fines.
  

• Agencies like theSingapore Health Sciences Authority (HSA) have been actively investigating intoxication cases involving etomidate-laced vapes. In several instances, teens were found to be intoxicated in public, prompting seizures and enforcement action.
  

Summary: Why This Matters

Final Takeaway

Etomidate in vapes is a highly dangerous, medically controlled drug being misused in consumer products. Its rapid sedative effects, potential to disrupt adrenal function, and risk of severe psychological symptoms make it particularly hazardous. With strict penalties now in place across parts of Asia—including prison, fines, and even caning—this isn’t just a health concern—it’s a serious legal one.

Avoid these products entirely—and if you ever suspect someone has been exposed, seek medical attention immediately.